Gastrin-Releasing Peptide-Induced Down-Regulation of Tumor Suppressor Protein PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome Ten) in Neuroblastomas

摘要

The authors identified presence of decreased expression of tumor suppressor protein PTEN in a higher percentage of undifferentiated neuroblastomas. Human neuroblastoma cells stably transfected to overexpress gastrin-releasing peptide receptor demonstrated increased cell growth rate, decreased expression of PTEN gene, and protein. PTEN may be an important tumor-suppressor gene in neuroblastomas.